It will be used under an Emergency Use Authorization external icon (EUA) or Investigational New Drug application external icon (IND) if ACAM2000® is depleted, is not readily available, or on a case-by-case basis for individuals with an allergy to a component of ACAM2000®.ĪCAM2000® and APSV are both administered as a single dose by the percutaneous route using the multiple puncture technique. APSV has a similar safety profile to ACAM2000® and is also held by the Strategic National Stockpile for use in a smallpox emergency. Food and Drug Administration (FDA) and will be used if there is ever a smallpox emergency. ACAM2000 ® and APSV ConsiderationsĪCAM2000® is licensed by the U.S. The Advisory Committee on Immunization Practices (ACIP) is currently evaluating JYNNEOS TM for the protection of people at risk of occupational exposure to orthopoxviruses in a pre-event setting. For more information, refer to the Clinical Guidance for Smallpox Vaccine Use in a Postevent Vaccination Program.
#Vaccine stockpile full#
Full documentation of vaccine-related clinical information and implementation considerations are found in the Vaccination section for Clinicians. The following highlighted considerations are not comprehensive. There are three different smallpox vaccines that each require distinct implementation considerations in a smallpox emergency vaccination strategy: ACAM2000®, APSV, and JYNNEOS TM (also known as Imvamune or Imvanex). The MCM coordinator will allocate vaccine to local areas, depending upon the circumstances of the emergency. In a smallpox emergency, the SNS external icon will coordinate with the Medical Countermeasures (MCM) coordinator or the preparedness office in the state or territorial health department. The Strategic National Stockpile (SNS) external icon has stockpiled enough smallpox vaccine to vaccinate every person in the United States. If there are not enough personnel to trace and vaccinate all contacts quickly enough, public health authorities may augment ring vaccination with a mass vaccination (community-wide) strategy. This strategy was used to successfully eradicate smallpox in the late 20 th century. In a smallpox emergency, the first-line vaccination strategy will be ring vaccination.